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Also available in 5 mg and bulk. Please contact Fisher for quotes. Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kB, resulting in the suppression of secretion of uPA. Purity 95%
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Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARalpha agonist, with pharmacological activity. Purity 98.53%
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Galunisertib (LY2157299) is a potent TGF? receptor I (T?RI) inhibitor with IC50 of 56 nM in a cell-free assay. Phase 2/3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 nM against EGFRL858R and 1 nM against EGFRL858R/T790M. It is effective in inhibiting EGFR phosphorylation in both sensitizing and T790M resistant EGFR mutant cell lines, demonstrating potent activity at low nanomolar concentrations. The compound also exhibits improved pharmacokinetic properties in rats, reduced hERG affinity, and improved IGF1R margins, showing excellent efficacy in preclinical tumor models.
Irreversible and mutant selective EGFR inhibitor
Potently inhibits EGFR phosphorylation in T790M mutant cell lines
Effective against sensitizing EGFR mutant cells
Shows improved pharmacokinetic properties and safety margins
Demonstrates efficacy in tumor-bearing mice
Soluble in water and DMSO for various applications
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